Expression of PTEN and MGMT protein in gynecomastia
- VernacularTitle:PTEN与MGMT蛋白在男性乳房发育症中的表达
- Author:
Lingdong ZHU
;
Jinglong CAI
;
Hong DONG
;
Chengjun ZHOU
- Publication Type:Journal Article
- Keywords:
gynecomastia;
PTEN gene;
O6-methylguanine-DNA methyltransferase (MGMT);
immunohistochemistry
- From:
Basic & Clinical Medicine
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the expression of a novo tumor suppressor gene PTEN and DNA direct repair enzyme MGMT in gynecomastia. Methods Immunohistochemical SP method was used to detect expression of PTEN and MGMT protein in 68 cases of gynecomastia(experiment group) and 24 cases of mammary gland of control group. The selected examples were divided into three different age groups and three different histological types. Results The PTEN and MGMT protein were all expressed in nucleusr of ductal cellula epithelialis. The expression level of PTEN and MGMT proteins in gynecomastia was significantly lower than that of mammary gland of control(P
