Effects of SLC concentration gradient on suppression of tumor cell immune escape
- VernacularTitle:次级淋巴组织趋化因子浓度梯度抑制肿瘤细胞免疫逃逸
- Author:
Sha WU
;
Xiaomei YUAN
;
Huifen ZHU
;
Guanxin SHEN
- Publication Type:Journal Article
- Keywords:
secondary lymphoid tissue chemokine;
tumor cell;
immune escape
- From:
Basic & Clinical Medicine
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of SLC concentration gradient on suppression of tumor immune escape. Methods According to different SLC concentration, there were six groups. The HLA-Ⅰexpression and apoptosis of MCF-7 were detected with FCM,and intracellular BCL-2 expression was analyzed by western blot. The production of TGF-? was detected with ELISA. Results In a certain range of concentration gradient, following SLC increase, HLA-Ⅰexpression level on MCF-7 was improved, and apoptosis was induced but BCL-2 expression was enhanced. Moreover, the secretion of TGF-? was suppressed. Conclusion SLC inhibites tumor immune escape.
