Model for pancreatic cancer in rats and the count of pancreatic myofibroblast
- VernacularTitle:大鼠胰腺癌模型及胰腺成肌纤维细胞计数
- Author:
Shan LIANG
;
Zhulin YANG
;
Xiongying MIAO
;
Yanchun LI
;
Yaxiang JIANG
- Publication Type:Journal Article
- Keywords:
pancreatic neoplasms;
animal model;
myofibroblast
- From:
Basic & Clinical Medicine
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a pancreatic cancer model in Sprague Dawley(SD) rats,and to study the distribution and the counts of myofibroblast(MF) in pancreatic cancer and non-cancerous pancreatic tissues.MethodsDirectly implanted DMBA into pancreas parenchyma of SD rats and established TSA intervening group and control group. The carcinogenesis of rats executed within 3～5 months were inspected by HE stain and microscopy for pathomorphological changes.Myofibroblast(MF) was stained by Heidenains method. Results (1)The prevalence of pancreatic cancer in experimental group was 48.7%(18/37), including 17 pancreatic ductal adenocarcinoma and 1 fibrosarcoma. The prevalence of pancreatic cancer in intervering group was 33.3%(12/36), including 11 pancreatic ductal adenocarcinoma and 1 fibrosarcoma. The maximal diameters of tumor mass of experimental group was higher than that of intervering group (P
