Toxic effect of formaldehyde on reproduction and heredity in male mice
- VernacularTitle:甲醛对雄性小鼠的生殖遗传毒性
- Author:
Shenyang XING
;
Lin YE
;
Nannan WANG
- Publication Type:Journal Article
- Keywords:
formaldehyde;
fertility;
dominant lethal test;
spermatozoa aberrations;
micronuclei
- From:
Journal of Jilin University(Medicine Edition)
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the effects of formaldehyde on the process of sperm development and reproductive capacity in male mice and the micronucleus rate of liver cells from offspring.Methods The mice were randomly divided into negative control group(NC),formaldehyde exposed group and positive control group (PC).The exposed dose was 21 mg?m-3 (1/24 LC50),42 mg?m-3 (1/12 LC50) and 84 mg?m-3 (1/6 LC50),respectively. 12 male mice were included in each group.Male mice from different formaldehyde exposed groups were inhaled with formaldehyde for 2 h one day,6 d each week,lasted for 13 weeks.The aberration rate of sperm in male mice and the micronucleus rate of liver cells from offspring were observed,and the reproductive capacity of male mice was detected by dominant lethal test.Results The aberration rates of sperm in mice from different formaldehyde exposed groups were significantly higher than that in negative control (P
