Expressions of nitric oxide and plasminogen activator inhibitor type-1 in rabbit models of atherosclerosis and interference effect of atorvastatin
- VernacularTitle:兔动脉粥样硬化模型中NO和PAI-1的表达及阿托伐他汀的干预作用
- Author:
Yushuang YANG
;
Xueyu LI
;
Wei MA
;
Ping YANG
- Publication Type:Journal Article
- Keywords:
atherosclerosis;
nitric oxide;
plasminogen activator inhibitor type-1;
atorvastatin
- From:
Journal of Jilin University(Medicine Edition)
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05).The levels of serum TC in groups A,B,and C were (23.51?10.58),(14.27?3.51)and(1.36?0.33)mmol?L-1, respectively; the levels of serum LDL in groups A,B,and C were (21.39?10.00),(14.23?4.01)and(0.72?0.35)mmol?L-1;there were significant differences between three groups (P0.05).Conclusion High-fat diet has no significant effect on the expressions of NO and PAI-1 in atherosclerosis rabbits .Atorvastatin can increase the expression of NO and decrease the expression of PAI-1,and can inhibit the progression of atherosclerosis.
