Protective effect of heme oxygenase-1 induced by doxorubicin on hepatic ischemia-reperfusion in rats
- VernacularTitle:阿霉素诱导亚铁血红素氧化酶-1对大鼠肝脏缺血再灌注的保护作用
- Author:
Haishan ZHANG
;
Xuewen ZHANG
;
Damin WANG
;
Dequan LIU
;
Deheng ZHANG
- Publication Type:Journal Article
- Keywords:
doxorubicin;
heme oxygenase;
reperfusion injury;
ischemia;
liver;
rats,Wistar
- From:
Journal of Jilin University(Medicine Edition)
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05).The results of Western blotting and immunohistochemical method showed that HO-1 protein expression increased in DOX group and DOX-IR group,and was negative in normal group.More distruction of ultrastructural changes of hepatic cells in IR group was found than in DOX-IR group by transmission electron microscope.Conclusion Doxorubicin pretreatment could protect the liver from ischemia-reperfusion injury,which may be related to HO-1 expression induced by doxorubicin,low dosage of doxorubicin does little harm to rat liver.
