Expression of matrix metalloproteinase-2 in patients with renal fibrosis and its clinical significance
- VernacularTitle:慢性肾小球肾炎患者血清MMP-2表达及临床意义
- Author:
Ping LUO
;
Lan HUANG
;
Xuehong LU
;
Dongmei ZHANG
- Publication Type:Journal Article
- Keywords:
gelatinase A/blood;
glomerulonephritis/blood;
fibrosis
- From:
Journal of Jilin University(Medicine Edition)
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the change of matrix metalloproteinase-2 (MMP-2) in the development of renal fibrosis and evaluate the diagnostic value of blood MMP-2 level in renal fibrosis.Methods Thirty three patients with chronic glomerulonephritis were divided into proliferation group(n=18) and fibrosis group(n=15) according to renal fibrosis degree in renal pathology.Another 8 healthy subjects were used as control group.The levels of pro-MMP-2 and MMP-2 in serum were measured with the method of SDS-PAGE enzymography.Then the levels of pro-MMP-2 and MMP-2 in serum were compared between various groups.Results The serum MMP-2 level in proliferation group was much higher than that in control group(P0.05).Conclusion There is a significant difference of serum MMP-2 between suffering group and normal control group.Therefore the detection of serum MMP-2 level can be conducive to understand the development of disease and estimate prognosis.
