Neurodevelopmental Changes in Social Reinforcement Processing: A Functional Magnetic Resonance Imaging Study.
10.9758/cpn.2017.15.4.369
- Author:
Soonjo HWANG
1
;
Harma MEFFERT
;
Michelle R VANTIEGHEM
;
Stuart F WHITE
;
Stephen SINCLAIR
;
Susan Y BOOKHEIMER
;
James BLAIR
Author Information
1. Department of Psychiatry, University of Nebraska Medical Center, Omaha, NE, USA. soonjo.hwang@unmc.edu
- Publication Type:Original Article
- Keywords:
Functional magnetic resonance imaging;
Social reward;
Ventromedial prefrontal cortex;
Amygdala;
Anterior insula;
Context-dependent psychophysiological interaction
- MeSH:
Adolescent;
Amygdala;
Fractals;
Gyrus Cinguli;
Healthy Volunteers;
Humans;
Learning;
Magnetic Resonance Imaging*;
Oxygen;
Prefrontal Cortex;
Reinforcement, Social*;
Reward;
Young Adult
- From:Clinical Psychopharmacology and Neuroscience
2017;15(4):369-381
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: In the current study we investigated neurodevelopmental changes in response to social and non-social reinforcement. METHODS: Fifty-three healthy participants including 16 early adolescents (age, 10–15 years), 16 late adolescents (age, 15–18 years), and 21 young adults (age, 21–25 years) completed a social/non-social reward learning task while undergoing functional magnetic resonance imaging. Participants responded to fractal image stimuli and received social or non-social reward/non-rewards according to their accuracy. ANOVAs were conducted on both the blood oxygen level dependent response data and the product of a context-dependent psychophysiological interaction (gPPI) analysis involving ventromedial prefrontal cortex (vmPFC) and bilateral insula cortices as seed regions. RESULTS: Early adolescents showed significantly increased activation in the amygdala and anterior insula cortex in response to non-social monetary rewards relative to both social reward/non-reward and monetary non-rewards compared to late adolescents and young adults. In addition, early adolescents showed significantly more positive connectivity between the vmPFC/bilateral insula cortices seeds and other regions implicated in reinforcement processing (the amygdala, posterior cingulate cortex, insula cortex, and lentiform nucleus) in response to non-reward and especially social non-reward, compared to late adolescents and young adults. CONCLUSION: It appears that early adolescence may be marked by: (i) a selective increase in responsiveness to non-social, relative to social, rewards; and (ii) enhanced, integrated functioning of reinforcement circuitry for non-reward, and in particular, with respect to posterior cingulate and insula cortices, for social non-reward.
