Detection of chromosome aberration rate and micronucleus rate in patients with esophageal carcinoma before and after radiotherapy and clinical significances
- VernacularTitle:食管癌患者放射治疗前后外周血淋巴细胞染色体畸变率和微核率的检测及临床意义
- Author:
Lei YU
;
Tiejun WANG
;
Jianfeng WANG
;
Libo LIU
;
Guizhi JU
- Publication Type:Journal Article
- Keywords:
esophageal neoplasms/radiotherapy;
chromosome aberrations;
micronuclei
- From:
Journal of Jilin University(Medicine Edition)
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the change of chromosome aberration rate and micronucleus rate in patients with esophageal carcinoma before and after radiotherapy.Methods Twenty one patients with esophageal carcinoma who were fit for conditions were divided into two groups randomly.GroupⅠ(n=10),patients received conventional radiotherapy(radiation field was regular rectangular shape);groupⅡ(n=11),patients received conformal radiotherapy(radiation field was same to the shape of target volume),1.8-2.0 Gy,one time a day,5 times a week,the total dose was 60-70 Gy.The peripheral blood was obtained before and after radiotherapy,chromosome aberration rate and micronucleus rate were detected.Results The chromosome aberration rate and micronucleus rate were increased after conventional radiotherapy than before (P0.05).Conclusion Compared with the conventional radiotherapy,the conformal radiotherapy can decrease cytogenetics damage,the detection of chromosome aberration rate and micronucleus rate can be regarded as a simple method to evaluate cytogenetics damage in esophageal carcinoma patients induced by radiotherapy.
