Effects of Depside Salt from Salvia Miltiorrhiza on Platelet Endothelial Nitric Oxide Synthase Activity
- VernacularTitle:丹参多酚酸盐对健康人血小板内皮型一氧化氮合酶活性的影响
- Author:
Wen WANG
;
Biao XU
- Publication Type:Journal Article
- Keywords:
Depside salt from Salvia Miltiorrhiza;
Platelet;
Nitric oxide synthase;
Nitric oxide
- From:
Chinese Journal of Hypertension
2007;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of depside salt from Salvia Miltiorrhiza on platelet endothelial nitric oxide synthase(eNOS) activity in health adults.Methods Peripheral venous blood was collected,platelets were isolated with gel-filtration chromatography and incubated with eNOS agonist histamine,eNOS inhibitor L-NAME and different concentrations of depside salt from Salvia Miltiorrhiza(0.1,1,10,100,1000 mg/L) for 30 minutes,then eNOS activity was measured as formation of 3H-L-citrulline from 3H-L-arginine.Results(1)Platelet eNOS activity was significantly inhibited after incubated platelets with L-NAME and increased after incubated with histamine(P
