Effect of early-stage continuous blood purification on the expression of cytokines in pig lungs during multiple organ dysfunction syndrome
- VernacularTitle:早期血液净化对多器官功能障碍综合征肺细胞因子基因表达的影响
- Author:
Bing WANG
;
Guoen FANG
;
Liang TANG
;
Chenghui DU
- Publication Type:Journal Article
- Keywords:
Multiple organ dysfunction syndrome;
Continuous blood purification;
High volume hemofiltration;
Cytokine
- From:
Journal of Medical Postgraduates
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of continuous blood purification on the expression of cytokines in pig lungs during MODS.Methods:Twenty-five pigs were randomly divided into model group,control group and high volume hemofiltration(HVHF) group.Blood bio-chemical and organ function indexes were determined.Real-time quantitative PCR was used to determine the expression level of IL-6 mRNA and IL-8 mRNA and TNF-? mRNA. Results:After HVHF,the serum chemical and organ-function indexes were improved and the morbidity and mortality of MODS were much lower than those in model group.The expression level of IL-6 mRNA and IL-8 mRNA and TNF-? mRNA in the lung were reduced significantly compared with model group.And the expression level of cytokines associated mRNA in the lungs was interrelated with the rate of respiratory failure. Conclusion:HVHF could decrease the over-expression of cytokine mRNA in the lung after trauma when used at early period so that pulmonary function would be improved.
