The role for Neurotrophin 3 in proprioceptive sensory nerve
- VernacularTitle:Neurotrophin 3对本体感觉神经作用的研究进展
- Author:
Rong WANG
;
Yong QIU
- Publication Type:Journal Article
- Keywords:
Neurotrophin 3;
Proprioceptive neuron;
Dorsal root ganglion;
Muscle spindle
- From:
Journal of Medical Postgraduates
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Neurotrophin 3(NT-3) is required for proprioceptive neuron survival and physiological function.During embryonic development,NT-3 deficient in developing muscle dues to loss of proprioceptive neurons in dorsal root ganglia or their axons by apoptosis,and then to the absence of muscle spindles.The chemoattractant effect of NT-3 on dorsal root ganglion axons has been improved that NT-3 is a key requirement for the development of proprioceptive projection to motor neurons.Depletion of NT-3 in the period of adult educes to the decline of the function of proprioception.NT-3 has extensive protective effect on proprioceptive neuron and enhances them to restore the normal physiological function under the pathological state.
