Association of EPHX2 polymorphism G860A with hypertension in middle ages

VernacularTitle:中年人中环氧化物水解酶2基因遗传多态G860A与原发性高血压相关性的研究
Author: Yiping BA ; Yiqin WU ; Bin LIU
Publication Type:Journal Article
Keywords: Epoxide hydrolases/GE; Hypertension/GE
From: Journal of Chinese Physician 2011;13(7):892-894,899
CountryChina
Language:Chinese
Abstract: Objective To investigate the association between the EPHX2 polymorphism G860A and the risk of hypertension in mild ages. Methods In a hospital based case-control study, one common polymorphism C860A in EPHX2 gene in a case-control study of 100 hypertension and 300 age- and sex frequency - matched disease-free controls were genotyped in a Southern Chinese population. SAS 9. 13 was used toanalysis the polymorphism and hypertension risk. Results Genotype frequencies of EPHX2 G860Alocus between the cases and the controls were significantly different (P =0. 01). Compared with the most common 860GG genotype, the 860GA heterozygote had an increased risk of hypertension (adjusted OR =1.98; 95%CI = 1.19 -3.51), the AA homozygote had a further increased risk of hypertension (adjusted OR =2. 84; 95%CI = 1.01 -6. 11). There was a significant trend for an allele dose effect on risk of hypertension (P trend = 0. 03). Conclusions EPHX2 polymorphism G860A is associated with an increased risk of hypertension, and the 860A variant may be a marker for susceptibility to hypertension.