DNA Prime-BCG Boost Vaccination Strategy Improved The Protective Efficacy Against M. tuberculosis H37Rv in Mice
- VernacularTitle:DNA疫苗初免-BCG加强免疫法提高小鼠抗结核分枝杆菌感染效率的研究
- Author:
Min LI
;
Dahai YU
;
Hong CAI
- Publication Type:Journal Article
- Keywords:
M.tuberculosis, DNA vaccine, BCG, immune response, Th1 type cytokine, protective efficacy
- From:
Progress in Biochemistry and Biophysics
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
The immunogenicity and protective efficacy of combined DNA priming, Bacillus Calmeette Guerin(BCG) boosting vaccination in mice were examined. Following intravenous challenge with virulent M. tuberculosis H37Rv, the BCG boost approach resulted in significant protection in both lungs (1.3, P
