Involvement of COX-2 in antagonism to heme oxygenase-1 on cardioprotection from anoxia/reoxygenation induced injury in rats
- VernacularTitle:环氧化酶-2参与血红素氧化酶1对抗大鼠心肌缺氧-复氧的损伤
- Author:
Yang WANG
;
Hejing XU
;
Wantie WANG
;
Yingying CHEN
;
Yueliang SHEN
;
Youai DU
- Publication Type:Journal Article
- Keywords:
heart;
anoxia/reoxygenation;
heme oxygenase-1;
cyclooxygenase-2
- From:
Basic & Clinical Medicine
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of HO-1 in the protection of rat heart from anoxia/reoxygenation induced injury and its underlying mechanism.Methods LVEDP,LVDP and dp/dtmax were analyzed by the Langendorff method in isolated rat heart.Lactate dehydrogenase(LDH), infarct area,COHb and 6-keto-PGF1? were further determined in the experiment.Results After intraperitoneal injection of HO-1 inducer hemin,CO concentration in rat blood enhanced(P
