Over-expression of extracellular signal-regulated kinase 1/2 and transforming growth factor ?1 in heart of spontaneous hypertensive rat
- VernacularTitle:ERK1/2和TGF-?1在自发性高血压大鼠心脏中的表达上调
- Author:
Lin ZHAO
;
Jianzhong ZHANG
;
Quan LIU
- Publication Type:Journal Article
- Keywords:
hypertension;
heart;
extracellular signal-regulated kinase 1/2;
transforming growth factor ?1;
vascular smooth muscle cell
- From:
Basic & Clinical Medicine
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of extracellular signal-regulated kinase 1/2(ERK1/2) and transforming growth factor ?1(TGF-?1) in heart of spontaneous hypertensive rat.Methods The expression of ERK1/2 and TGF-?1 was determined by immunohistochemistry and Western blot.Results In arteriole of the heart of 8,16,and 20 week-old SHR,the rate of positive ERK1/2 staining at the endothelium(15.38%,76.97% and 72.72%,respectively) and at the vascular smooth muscle cell(VSMC) of 16 and 20 week-old SHR(5.49% and 6.83%,respectively)were significantly higher than that of control group(P
