Expressions of tissue factor and tissue factor pathway inhibitor in the atherosclerotic plaque
- VernacularTitle:粥样硬化斑块中组织因子和组织因子途径抑制物的表达
- Author:
Na LI
;
Lianfeng CHEN
;
Yuannan KE
;
Wenling ZHU
- Publication Type:Journal Article
- Keywords:
tissue factor;
tissue factor pathway inhibitor;
atherosclerosis
- From:
Basic & Clinical Medicine
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the expression and location of TF and TFPI in femoral artery atherosclerotic plaque.Methods We detected the expressions and locations of TF and TFPI in femoral artery atherosclerotic plaque by immunohistochemical and double-stain immunohistochemical method.We detected TF mRNA and TFPI mRNA expressions in atherosclerotic plaque by RT-PCR,with the normal umbilical artery as a control.ResultsThe normal umbilical artery contained little TF,TFPI and their mRNA in the adventitia.A great deal of TF,TFPI and their mRNA were found in the tunica intima of the femoral artery atherosclerotic plaque.Conclusion Expression of TF,TFPI and their mRNA of all types of cells and stroma in the proliferative tunica intima.
