Increased expressions of NGF and its receptor P75 in liver of CCl_4-induced toxic rats
- VernacularTitle:NGF及其受体P75在四氯化碳中毒性大鼠肝组织中表达增强
- Author:
Xin CHEN
;
Huiqing JIANG
;
Zhanguo HE
;
Yuzhen WANG
;
Caixia HU
- Publication Type:Journal Article
- Keywords:
NGF;
RT-PCR;
Western blot;
hepatic fibrosis;
rat
- From:
Basic & Clinical Medicine
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective By observing the changes in NGF and its receptor P75 in liver of CCl4-induced toxic rats and to evaluate the role of NGF in the mechanism of hepatic fibrosis.Methods The expressions of NGF mRNA and its receptor P75 were detecteded by both hemi-quantitative RT-PCR and Western blot analysis.Results The expressions of NGF mRNA and its receptor P75 in liver of CCl4-induced toxic rats at 24th hour group were higher than that in control group(P
