Inhibition of endostatin on growth of ovarian cancer cell line SKOV_3
- VernacularTitle:内皮抑素对人卵巢癌细胞系生长的抑制作用
- Author:
Meimei LIU
;
Peiling LI
;
Lihua SUI
- Publication Type:Journal Article
- Keywords:
ovarian cancer cell;
endostatin;
apoptosis;
BCL-2/BAX
- From:
Basic & Clinical Medicine
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the inhibitory effect of endostatin on ovarian cancer cell line SKOV3 and to investigate the possible mechanism of the inhibition.Methods The effect of endostatin on SKOV3 cell proliferation was studied by means of MTT.The cell apoptosis was detected by transmission electronic microscopy.BCL-2 and BAX expressions were measured in SKOV3 cells treated by endostatin by immunocytochemistry,RT-PCR and Western blot.Results Endostatin inhibited SKOV3 cell proliferation(P
