Significance of E-cadherin/catenin adhesion complex expression in nasopharyngeal carcinoma
- VernacularTitle:上皮钙黏素/链接素黏附复合体在鼻咽癌组织中的表达及意义
- Author:
Qiang WEI
;
Minyi WEI
;
Xiujiu LIANG
;
Hua LI
;
Jingyan LU
- Publication Type:Journal Article
- Keywords:
nasopharyngeal neoplasms;
E-cadherin;
beta-catenin;
alpha-catenin;
immunohistochemistry
- From:
Basic & Clinical Medicine
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To elucidate the expression pattern of E-cadherin/catenin adhesion complex and its association with pathologic features in nasopharyngeal carcinoma(NPC).Methods Fifty-two non-keratinizing NPC specimens with adjacent non-neoplastic mucosa were examined for E-cadherin,?-CATenin,?-CATenin.Results Abnormal expression rate of E-cadherin,?-catenin and ?-catenin in NPCs were 48.1%(25/52),32.7%(17/52) and 34.6%(18/52),respectively,whereas all adjacent non-neoplastic tissues normally expressed these proteins.Difference of expression of E-cadherin,?-catenin and ?-catenin between tumor tissues and non-cancerous tissues was statistically significant(P
