Comparison of bioavailability of rifampicin in fixed dose combination (3-FDC) with standard separate tablet
- Author:
Le Thi Luyen
- Publication Type:Journal Article
- Keywords:
rifampicin
- MeSH:
Biological Availability;
Rifampin;
Tablets
- From:Journal of Practical Medicine
2005;510(4):85-88
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Study on 12 healthy volunteers using 2 types of medication: rifampicin, isoniazid, and pyrazinamid standard separate tablets and in fixed dose combination of rifampicin + isoniazid + pyrazinamid (3- FDC). Results: rifampicin is one of essential anti-tuberculosis drugs that have most advantages of pharmacodynamics on both intra- and extra-cellular bacteria. Cmax (maximum concentration in plasma) and AUC 0-∞ (Area Under the Concentration-Time Curve) of rifampicin in 3- FDC is lower than that in standard separate tablet, Tmax (Time to Maximum Plasma Concentration) of rifampicin in 3- FDC is more slowly than in standard separate tablet. These findings showed that the bioavailability of rifampicin in FDC tablet that was using in treating tuberculosis is much lower than in standard separate tablet.
