An empirical study on amikacin and ceftriaxone-induced release of endotoxin from bacterium
- VernacularTitle:丁胺卡那霉素和头孢曲松诱导细菌释放内毒素的实验研究
- Author:
Lan LIU
;
Yuqiang ZHENG
;
Chunmei JING
;
Wei XIE
- Publication Type:Journal Article
- Keywords:
escherichia coli;
amikacin;
ceftriaxone;
endotoxin;
releasing experiment
- From:
Chinese Journal of Clinical Laboratory Science
1985;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
2h.The shape of bacterium was changed by amikacin from sphero-rhabditiform to dolicho-rhabditiform,while by ceftriaxone changed from rhabditiform to long-chain-form or filament-form.Conclusion The capability of ceftriaxone-induced release of endotoxin from Escherichia coli is significantly stronger than that of amikacin,and the morphologic changes of bacteria caused by ceftriaxone were more significant.For clinical treatmentg of infectious diseases the first dosage of medication should increase to reach the effective bactericidal concentration but not the bacteriostasis concentration in order to receive better therapeutic effects.
