Soluble dispersive mixture of chicken collagen type Ⅱ delays the morphological changes of articular cartilage in rats with osteoarthritis: Comparison among different oral doses and excipients
- VernacularTitle:可溶性鸡Ⅱ型胶原分散组合物延缓骨关节炎大鼠关节软骨形态学的变化:不同口服剂量及赋形剂比较(英文)
- Author:
Donghong XU
;
Weiming SHEN
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2007;0(27):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05). ②Therapeutic study: The Mankin's score of OA group was higher than high or low SmCCⅡ group (6.96?1.02), (3.08?0.45), (4.00?0.94) respectively, P 0.05). CONCLUSION: SmCCⅡ can delay the degradation of articular cartilage of OA rats and maybe effective for OA prevention or treatment. The mechanism maybe related to SmCCⅡ reducing the synthesis of MMP-13, MMP-9 and Cath K at transcriptional level.
