Relationship between vascular endothelial growth factor-C expression and tumor infiltrating dendritic cells in gastric cancer
- VernacularTitle:胃癌组织中血管内皮生长因子C与肿瘤浸润性树突状细胞的相关性
- Author:
Chao LIU
;
Li WANG
- Publication Type:Journal Article
- Keywords:
gastric carcinoma;
vascular endothelial growth factor C;
tumor infiltrating dendritic cells
- From:
Chinese Journal of Cancer Biotherapy
1995;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the roles of vascular endothelial growth factor C(VEGF-C) and tumor infiltrating dendritic cells(TIDC) in invasion and metastasis of gastric cancer cells and to investigate the relationship between VEGF-C expression and TIDC infiltration in gastric cancer.Methods:Fifty-two patients,who were pathologically diagnosed with gastric carcinoma and received gastrectomy in the First Affiliated Hospital of Chongqing Medical University from 2004 to 2006,were enrolled in this study.The expression of VEGF-C and infiltration of dendritic cells were examined by immunohistochemical staining(S-ABC method),using anti-VEGF-C polyclonal antibody and anti-S-100 polyclonal antibody,and the relationship between them was investigated.Results:(1) In poorly differentiated and well/moderately differentiated cancer patients,the rates of positive of VEGF-C expression were 75.86% and 44.23%,respectively(P 0.05);the rates of serosa invasion in the high density group and low density TIDC patients were 36.36% and 70%,respectively(P
