Auto-dendritic cell-vaccine in treatment of patients with condyloma acuminatum:a clinical study
- VernacularTitle:自身树突状细胞疫苗治疗尖锐湿疣的临床研究
- Author:
Xiaoqin SHI
;
Junquan LIU
;
Fuxing CHEN
;
Weifeng CHEN
- Publication Type:Journal Article
- Keywords:
dendritic cells;
human papillomavirus;
condyloma acuminatum;
lymphocyte proliferation
- From:
Chinese Journal of Cancer Biotherapy
1995;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the effects of auto-dendritic cell vaccine on T cells of patients with condyloma acuminatum(CA) related human papilloma virus(HPV) and its clinical outcome.Methods:73 patients with condyloma acuminata(CA) in the present study were positive of HPV-DNA and have been unsuccessfully treated with freezing,laser,or electric therapy combined with interferon anti-virus treatment for half a year.The peripheral blood samples were harvested from patients and the monouclear cells were extracted to cultivate DCs in presence of cytokines.Auto DCs were sensitized with corresponding HPV virus antigen of a patient to prepare the auto-dendritic cell vaccine.Then the vaccine were cultivated with auto T-cells and the proliferation of T cells were examined.Meanwhile,the auto-DC vaccine(1-4)?107 was also injected into the patients' inguinal lymph glands and its therapeutic effectiveness was observed.Results:The prepared DC-vaccine significantly promoted the proliferation of auto T cells compared with control group(P
