Effects of polysaccharide from Ecklonia kurome on pulmonary interstitial fibrosis induced by bleomycin in rats
- VernacularTitle:昆布多糖对博来霉素诱导的大鼠肺间质纤维化的影响
- Author:
Shan JIANG
;
Lei SHAO
;
Xiaoguang DU
;
Xianliang XIN
;
Meiyu GENG
- Publication Type:Journal Article
- Keywords:
polysaccharide from Ecklonia kurome;
pulmonary interstitial fibrosis;
bleomycin
- From:
Chinese Journal of Marine Drugs
1994;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of polysaccharide from Ecklonia kurome on pulmonary interstitial fibrosis induced by bleomycin in rats.Methods The pulmonary interstitial fibrosis model was established by endotracheal injection of bleomycin in rats.25,50,100mg?mL-1 doses of the polysaccharide from Ecklonia kurome were ig administered to the rats respectively,and the contants of hydroxyproline in rat lung were determined by kits at 0,3,7,14,28 d after the model was made.Results At 7,28d after the model was made,the treatment groups of middle and high doses compared with the model group showed signi-ficantly decrease of hydroxyproline level(P
