Study the relationship between the monocyte chemoattractant protein-1 gene -2518G/A polymorphism and cerebral infarction of Han population in Chinese Hunan district
- VernacularTitle:单核细胞趋化蛋白-1基因-2518G/A多态性与中国湖南地区汉族人群脑梗死关系的研究
- Author:
Shiyan CHEN
;
Zhijian ZHANG
;
Xiuli WU
- Publication Type:Journal Article
- Keywords:
cerebral infarction;
monocyte chemoattractant protein-1;
gene polymorphism
- From:
Journal of Clinical Neurology
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between monocyte chemoattractant protein-1 (MCP-1) gene -2518G/A polymorphism and cerebral infarction(CI) of Han population in Chinese Hunan district.Methods The -2518G/A polymorphism in MCP-1 gene was detected by polymerase chain reaction-restriction fragment length polymorphism analysis (PCR-RFLP) and DNA sequencing in 162 patients with CI (CI group) and 150 normal controls (NC group). The serum level of MCP-1 in the two groups was determined by enzyme-linked immunosorbent assay (ELISA).Results In CI group, genotypic frequency of GG was 39.5%, GA was 37.0%, and AA was 23.5%. The allele frequency of G was 58.0% and A was 42.0%. In NC group, genotypic frequency of GG was 27.3%, GA was 39.3%, and AA was 33.4%. The allele frequency of G was 47.0% and A was 53.0%. The frequencies of MCP-1 -2518GG genetype and G allele in CI group were significantly higher than those in CI group (all P
