Diagnostic value of the immune intensity of platelet ?-amyloid precursor protein and isoforms proportion for Alzheimer's disease
- VernacularTitle:血小板?-淀粉样肽前体蛋白免疫强度及异构体比率对Alzheimer病的诊断价值
- Author:
Shouru XUE
;
Xiaowang YANG
- Publication Type:Journal Article
- Keywords:
Alzheimer's disease;
?-amyloid precursor protein;
platelet
- From:
Journal of Clinical Neurology
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore diagnostic value of the immune intensity of platelet ?-amyloid precursor protein(APP) and isoforms proportion for Alzheimer's disease(AD).Methods The APP immune intensity of platelets was evaluated by flow cytometric detection and the isoforms proportion of APP130/APP106 was also detected by Western Blot analysis in 31 AD cases, 22 vascular dementia (VD) patients , 28 neural degeneration patients and 30 healthy elders.Results There was no significant difference of APP immunity in the each group. The ratio of APP130/APP106 was significantly lower in the AD group compared with the groups VD, degenerative disorder and healthy elders(all P
