Repaired effects of autotransplantation of bone marrow-derived neural stem cells on hippocampus of epilepsy rats
- VernacularTitle:骨髓源性神经干细胞自体移植对癫大鼠海马的修复作用
- Author:
Huanming WANG
;
Ruxiang XU
;
Xiaodan JIANG
- Publication Type:Journal Article
- Keywords:
bone marrow stromal cells;
neural stem cells;
transplantation;
hippocampus
- From:
Journal of Clinical Neurology
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the repaired effects of autotransplantation of bone marrow-derived neural stem cells (BMSCs) on hippocampus of epilepsy rats.Methods Male SD rats were randomly divided into groups normal control (NC),graft and non-graft .Under sterile condition, the BMSCs of rats were isolated, and under specific condition the BMSCs were cultured to induce and differentiate into neural stem cells(NSCs). Then the models of temporal lobe epilepsy were established in groups graft and non-graft , and the NSCs were autotransplanted into the right hippocampus of rats of graft group. The morphological changes of the hippocampus were observed at 1,2 ,4,8,16 weeks after the transplantation respectively.Results The number of hippocampal CA3 pyramid cells of groups non-graft and graft significantly decreased than that in NC group(all P
