Drug eluting stents in coronary interventional therapy
- VernacularTitle:药物洗脱支架在冠状动脉介入治疗中的应用
- Author:
An LIU
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2007;0(25):-
- CountryChina
- Language:Chinese
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Abstract:
OBJECTIVE: To introduce the current application of drug eluting stents in clinical practice, and investigate the advanced study of sirolimus and paclitaxel eluting stents. DATA SOURCES: An online research of Medline database was undertaken to identify the articles about drug eluting stents published between January 1996 and December 2006, with the keywords of "drug eluting stents, sirolimus eluting stents, paclitaxel-eluting stents", and language was limited to English; Meanwhile, the Chinese articles were retrieved in the Wanfang database from January 2000 to December 2006 by inputting the keywords "drug eluting stents, sirolimus eluting stents, paclitaxel eluting stents". STUDY SELECTION: Over 200 literatures were screened out, and those related with the clinical application of drug eluting stents were collected, subjecting as patients. Randomized or nonrandomized study and control or uncontrol group were all involved. Randomized control large sampling study was preferred for the similar content. Finally 30 articles were included. DATA EXTRACTION: Among 30 selected articles, 5 papers briefly introduced the characteristics of drug eluting stents, 10 papers discussed the mechanism of preventing and treating restenosis by sirolimus eluting stents and paclitaxel eluting stents, 15 papers referred to the clinical application of eluting stents. DATA SYNTHESIS: Drug eluting stent can inhibit the inflammatory reaction and cellular proliferation, delay the vascular endothelization, distinctly reduce the in-stent restenosis after percutaneous coronary intervention, and obviously develop the indication of Percutaneous intervention by releasing one or several bioactive substance to blood and surrounding tissues. Currently it is conformed in randomized control clinical trials that sirolimus eluting stents and paclitaxel eluting stents can decrease in-stent restenosis in patients with simple coronary artery stenosis, but the application on those with complex bifurcation affection and acute myocardial infarction is unknown. In addition, the high cost and in-stent thrombogenesis are also in debates. CONCLUSION: Drug eluting stents will be widely applied to reduce the in-stent restenosis and cardiovascular adverse events due to the advancement of interventional technique, modification of interventional instrument and appearance of anti-proliferation drug, which is more specific and lower poisonous and side effects.
