Mitochondrial dysfunction and atherogenesis
- VernacularTitle:线粒体功能障碍与动脉粥样硬化的发生
- Author:
Xiaomin CAI
;
Shisen JIANG
- Publication Type:Journal Article
- Keywords:
Mitochondrial Dysfunction;
Oxidative stress;
Reactive oxygen species;
Atherosclerosis
- From:
Journal of Medical Postgraduates
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Atherosclerosis is a multifactorial disease for which the molecular etiology of many of the risk factors is still unknown.Reactive oxygen species(ROS) mediate various signaling pathways that underlie vascular inflammation in atherogenesis: from the initiation of fatty streak development through lesion progress to ultimate plaque rupture.The mitochondrial respiratory chain is the major source of reactive oxygen species as byproducts of normal cell respiration.Mitochondria may also be important target for reactive oxygen species,which may lead to mitochondrial dysfunction.Moreover,in patients with mitochondrial diseases,vascular complications are commonly observed at an early age,often in the absence of traditional risk factors for atherosclerosis.The aim of this review is to summarize the data linking mitochondrial dysfunction to the pathogenesis of atherosclerosis.
