Estimating the genetic distance and protracting the phylogenetic tree by MICA-TM locus in different population
- VernacularTitle:利用MICA穿膜区微卫星多态性估算广东汉族和/或中外不同人群间遗传距离
- Author:
Tong SHEN
;
Mingliang FENG
;
Hui HUANG
- Publication Type:Journal Article
- Keywords:
Population;
MICA-TM;
Locus;
Genetic distance;
Phylogenetic tree
- From:
Chinese Journal of Blood Transfusion
1988;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the genetic polymorphism of the transmembrane region of the MICA locus in Guangdong Han population,and to protract the genetic distance in different populations.Methods DNA samples from 106 unrelated Han individuals were genotyped by PCR to analyze the frequencies of MICA alleles.The genetic distance was estimated and the phylogenetic tree was protracted by DISPAN Software.Results In total,5 alleles of MICA-TM were observed,they were A4,A5,A5.1,A6 and A9.MICA-TM A5 was the dominant allele(0.2877),whereas A4 was the least popular one(0.1321).From genetic distance and phylogenetic tree we made,the preliminary finding is that Chinese Hans may have migrated from southwest China to northern and southern China.Conclusion MICA-TM locus has high genetic polymorphism and obvious variance in different populations.Since the genetic distance could be estimated effectively through MICA-TM locus,it could serve as the genetic marker in human migration and evolution research.
