Ephrin B1 and RYK expression in DRG of rats after peripheral nerve injury
- VernacularTitle:外周神经损伤大鼠背根神经节中Ephrin B1及RYK受体表达的变化
- Author:
Yaobo LIU
;
Xin LI
;
Yaohua LI
;
Shun YU
- Publication Type:Journal Article
- Keywords:
dorsal root ganglion;
sciatic Nerve;
injury;
Ephrin B1;
Ry
- From:
Basic & Clinical Medicine
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study changes of expression in Ephrin and its receptors in DRG neurons after peripheral nerve injury. Methods A rat model of unilateral crushed sciatic nerve was prepared, and changes in the expression pattern of Ephrin B1, Eph B1、Eph B2、Eph B3、EphA4 and RYK in DRG neurons in the rats crushed unilateral sciatic nerve were estimated by the number of positive staining cells in DRG, and the percentage of positive cells as well as the cell size.Results After peripheral nerve injury, the expression of Ephrin B1 significantly decreased, but there was no change in expression of Eph B1、Eph B2、Eph B3 or Eph A4, RYK expression was intensely induced in DRG neurons. Conclusion Ephrin B1 and RYK showed very significant expression changes in ERG neurons after peripheral nerve injury, and may be a component factor process of peripheral never regeneration.
