Effect of interaction between smoking,alcohol drinking and polymorphisms of phase Ⅱ metabolic genes on the susceptibility of hepatocellular carcinoma
- VernacularTitle:Ⅱ相代谢酶基因多态性联合烟酒习惯对肝癌易感性的影响
- Author:
Shujia HE
;
Yongyao GU
;
Zhihong LIAO
- Publication Type:Journal Article
- Keywords:
hepatocellular carcinoma;
glutathion-s-transferase M1;
microsomal epoxide hydrolase polymorphism;
smoking and alcohol drinking
- From:
Basic & Clinical Medicine
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective This study intended to explore the relationship of the polymorphisms of phase Ⅱ metabolic genes (GSTM1 and EPHX1), smoking, alcohol drinking and their interactions on risk of hepatocellular carcinoma(HCC). Methods Using multiplex PCR and PCR-RFLP, the genotypes of GSTM1 and EPHX1 were analyzed in 105 patients with HCC and 151 health controls in Guangxi. The state of smoking and alcohol drinking were investigated. Results The frequency of the GSTM1 null genotype in cases was 64.76% and 50.99% in controls, which was significantly different(P
