Effects of ethinylestradiol and cyproterone acetate on endocrine metabolism in non-obese women with polycystic ovary syndrome
- VernacularTitle:炔雌醇环丙孕酮对非肥胖型多囊卵巢综合征患者内分泌代谢的影响
- Author:
Jieping ZHU
;
Yincheng TENG
;
Minfang TAO
- Publication Type:Journal Article
- Keywords:
polycystic ovary syndrome;
ethinylestradiol and cyproterone acetate tablet;
insulin sensitivity;
hyperandrogenism
- From:
Journal of Shanghai Jiaotong University(medical Science)
2010;30(2):168-170,185
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of ethinylestradiol and cyproterone acetate tablets(Diane-35)on endocrine metabolism in non-obese women with polycystic ovary syndrome(PCOS). Methods Fifty-three non-obese patients with PCOS were assigned to the 6-month treatment with Diane-35.Body mass index(BMI),waist to hip ratio(WHR),F-G score and acne score were recorded before treatment and at the end of the third and sixth cycle after treatment.Serum total testosterone,follicle stimulating hormone(FSH),luteinizing hormone(LH),LH/FSH,fast plasma glucose,fast insulin and insulin resistance index(HOMA-IR)were obtained at early follicular phase and at the end of the third and sixth month.Results There was no significant change in BMI and WHR after treatment.Compared with those before treatment.F-G score,acne score,serum total testosterone,LH and LH/FSH were significantly decreased at two time points after treatment (P<0.05).BMI and HOMA-IR in patients with insulin resistance were significantly higher at the end of the sixth cycle after treatment than those before treatment(P<0.05). Conclusion Diane-35 can improve hyperandrogenism in non-obese patients with PCOS.However,Diane-35 may aggravate insulin resistance in those with insulin resistance.
