Neurodegeneration-related Aminoacyl-tRNA Synthetases
- VernacularTitle:氨基酰-tRNA合成酶与神经退行性疾病
- Author:
Bin ZHU
;
Enduo WANG
- Publication Type:Journal Article
- Keywords:
aminoacyl-tRNA synthetase, tyrosyl-tRNA synthetase, glycyl-tRNA synthetase, alanyl-tRNA synthetase, neurodegeneration, Charcot-Marie-Tooth disease, Purkinje cell
- From:
Progress in Biochemistry and Biophysics
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Aminoacyl-tRNA synthetases (AARSs) catalyze aminoacylation of their tRNAs for protein biosynthesis. As belong to one of the most ancient and conserved enzyme family their additional functions in mammalian cells were focused recently. Mutations in tyrosyl-tRNA synthetase, glycyl-tRNA synthetase and alanyl-tRNA synthetase from patients and mice models were identified to cause two subtypes of Charcot-Marie-Tooth disease and cerebellar Purkinje cell loss, respectively. These mutations affect different functions of the three enzymes including aminoacylation, editing and unknown functions. These results combined AARSs with neurodegeneration and gave new sights into neuropathy.
