Effects of Levofloxacin on QTcd Interval in Elderly Patients Hospitalized with Acute Exacerbations of COPD
- VernacularTitle:左氧氟沙星对慢性支气管炎急性加重期老年患者QTc离散度影响
- Author:
Qian GUI
;
Jie CHEN
;
Rongrong TANG
;
Changqing ZHU
;
Yi CHEN
- Publication Type:Journal Article
- Keywords:
Acute exacerbations of COPD;
Levofloxacin;
QTc dispersion
- From:
Chinese Journal of Nosocomiology
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To study the effects of levofloxacin on QT correction dispersion(QTcd) interval in elderly patients hospitalized with acute exacerbations of COPD(AECOPD).METHODS Totally 124 patients received IV levofloxacin(500 mg qd) for 10-14 days.Evaluations included of 12-lead ECGs at baseline and blood examination before treatment,day 5 and after treatment.RESULTS QT correction(QTc) interval was no significant changes,but the QTcd interval was with significant prolongation.CONCLUSIONS IV levofloxacin could not cause QTc interval prolongation,but could make QTcd interval prolongation,which is a potential risk of arrhythmia in elderly patients with AECOPD.
