Effects of atorvastatin on expressions of peroxisome proliferators-activated receptor gamma and MMP-9 in atherosclerosis rabbits
- VernacularTitle:阿托伐他汀对家兔动脉粥样硬化模型PPAR?及MMP-9表达的影响
- Author:
Xiaomei WANG
;
Ling QIN
;
Yang LI
;
Kexin HUANG
- Publication Type:Journal Article
- Keywords:
atorvastatin;
peroxisome proliferators-activated receptor gamma;
matrix metalloproteinase-9
- From:
Journal of Jilin University(Medicine Edition)
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of atorvastatin on the expressions of peroxisome proliferators-activated receptor gamma(PPAR?)and matrix metalloproteinase-9(MMP-9)in atherosclerosis(AS) tissue.Methods Atherosclerotic rabbit models on aortas were established with the high-cholesterol diet,and animals were divided into control,model and atorvastatin groups(n=8).The expressions of PPAR? and MMP-9 and the effects of atorvastatin on them were observed by means of immunohistochemistry.Results The expression of PPAR? in model group(14.38%?2.58%)was higher than that in control group(7.82%?0.96%)(P
