Correlation between expressions of PTEN and C-myc in colorectal carcinoma
- VernacularTitle:结直肠癌组织抑癌基因PTEN和癌基因C-myc蛋白表达及其相关性
- Author:
Xuedong FANG
;
Hui REN
;
Yan ZHANG
;
Yu TIAN
- Publication Type:Journal Article
- Keywords:
colorectal neoplasms;
oncogene C-myc;
anti-oncogene PTEN;
immunohistochemistry
- From:
Journal of Jilin University(Medicine Edition)
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between the expressions of tumour suppressor gene PTEN and oncogene C-myc in colorectal carcinoma.Methods The expressions of PTEN and C-myc protein in normal colorectal mucosa(n=8), adjacent non-cancerous tissues(n=10) and primary colorectal carcinoma tissues(n=60) were observed by S-P immunohistochemical assay.Results Of 60 colorectal carcinoma tissues,C-myc protein was detected in 46 cases.The expression rate of C-myc in the primary colorectal carcinoma tissues(76.70%) was significantly higher than that in the normal(0) and adjacent non-cancerous tissues(10%)(P0.05).The positive expression rate of PTEN protein in the primary colorectal carcinoma tissues(25.00%,15/60) was significantly lower than that in the normal(100%) and adjacent non-cancerous tissues(90%)(P
