Expressions of heat shock protein 70,P27 and Bcl-2 protein in mucoepidermoid carcinoma of salivary glands and clinical significances
- VernacularTitle:涎腺黏液表皮样癌中Hsp70、P27、Bcl-2蛋白表达及临床意义
- Author:
Wanzhong YIN
;
Wenzhi SONG
;
Wei ZHU
;
Meihua LI
- Publication Type:Journal Article
- Keywords:
salivary gland neoplasms;
heatshock proteins 70;
cell cycle proteins P27;
Bcl-2
- From:
Journal of Jilin University(Medicine Edition)
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expressions of Hsp70,P27,Bcl-2 in mucoepidermoid carcinoma of salivary glands and clinical significances.Methods Forty cases of mucoepidermoid carcinoma of salivary glands were chosen and the expressions of Hsp70,P27,Bcl-2 were detected by the method of immunohistochemistry,10 cases of polymorphic adenoma were chosen as control group.Results Both Hsp70 and P27 were stained with aliomycin in nucleus and cytoplasm,the positive rates of them were 75% and 27.5%,respectively,there were significant differences compared with control group(P0.05).The expressions of Hsp70 and P27 had significant differences in different clinical stages,different histological grades and lymph node metastasis(P0.05).Conclusion The expressions of Hsp70 and P27 can be used to estimate prognosis of patients with mucoepidermoid carcinoma.Hsp70 and Bcl-2 can inhibit apoptosis by different ways.
