Expressions of MDM2 and VEGF in osteosarcoma tissue and clinical significances
- VernacularTitle:MDM2与VEGF在骨肉瘤组织中的表达及临床意义
- Author:
Jiayin LU
;
Dankai WU
;
Zhongli GAO
;
Yanying ZHAO
;
Hui LIU
- Publication Type:Journal Article
- Keywords:
osteosarcoma;
MDM2;
endothelial growth factors;
immunohistochemistry
- From:
Journal of Jilin University(Medicine Edition)
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relation of the expressions of MDM2 and VEGF in osteosarcoma with the pathological parameters and prognosis of the tumor.Methods The expressions of MDM2 and VEGF were detected with immunohistochemical(SP) method in specimens from 56 cases of osteosarcoma.The correlation between the expressions of MDM2,VEGF and pathological grade,metastasis and prognosis was analyzed statistically.while 8 cases of fibrous dysplasia of bone were used as negative control group.Results The positive rates of MDM2 and VEGF in osteosarcoma were 64.3%(36/56) and 67.9%(38/56),respectively .MDM2 and VEGF didn't express in negative control group.The expression of MDM2 and VEGF were not significantly correlated to the pathological grades of the osteosarcoma,but which were significantly correlated with tumor metastasis and prognosis(P
