Angiotensin converting enzyme gene polymorphism in children with Henoch-Schonlein purpura nephritis
- VernacularTitle:儿童紫癜性肾炎血管紧张素转换酶基因多态性分析
- Author:
Zhongmin FAN
;
Guangling LIU
;
Zhengkun XIA
;
Yuanfu GAO
- Publication Type:Journal Article
- Keywords:
Henoch-Schenlein Purpura nephritis;
Children;
Angiotensin coverting enzyme;
Gene polymorphism
- From:
Journal of Medical Postgraduates
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To invesgate the correlation between Angiotensin converting enzyme(ACE) gene polymorphism and Henoch-Schonlein purpura nephritis(HSPN) in children. Methods:According to the clinical features,pathological changes,48 HSPN children have been devided into 4 clinical types,Uab,I-GH,R-GH and NS type,and Ⅱ-Ⅳ 3 histological degrees respectively.The correlations between serum ACE level,ACE gene polymorphism and clinical presentation,pathlogical changs,effect to therapy were analyzed.Results:In the 48 patients,35(72.9%),4(8.3%),4(8.3%) and 5(10.5%) patients belonged to Uab type,I-GH type,R-GH type and NS type respectively.20(41.7%),19((39.6%)) and 9(18.7%) patients belonged to Ⅱ,Ⅲ and Ⅳ histological degrees respectively.5 patients had DD genotype,25 patients had ID genotype and 18 patients had II genotype.The mean serum ACE level of DD genotype patients was(39.60?11.40)U/L,which was significant higher than that of ID genotype patients[(24.29?11.62)(U/L) and II genotype patients(4.49?11.41)U/L](P
