Role of SREBP-1C and GRP-94 in hepatocytes lipids metabolism of mice
- VernacularTitle:SREBP-1C、GRP-94在小鼠肝细胞脂质代谢中的作用
- Author:
Danwen HUANG
;
Chungen YAN
;
Dongfang ZHU
;
Peihua NI
- Publication Type:Journal Article
- Keywords:
sterol regulatory element binding protein 1C;
glucose-regulated protein 94;
Homocysteine;
Lipids Metabolize;
Hepatocytes
- From:
Basic & Clinical Medicine
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of sterol regulatory element binding protein 1C (SREBP-1C) and glucose-regulated protein 94(GRP-94)in hyperhomocysteinmia and to evaluate the effects of endoplasmic reticulum stress proteins on hepatocytes lipids metabolism. Methods After hyperhomocysteinmia C57BL/6 mice model being induced by high methionine diet, TGE and CHO of Hepatocytes were determined, and the expression of SREBP-1C and GRP-94 was assessed by RT-PCR and Western blot. All data were compared to those in control group′s. Results The level of plasmic homocysteine(Hcy) and hepatocytes TGE or CHO of high methionine diet mice at different time point significantly ascended(P
