Expressions in FAS、FASL、FADD、 caspase-8 and their significant in esophageal carsinogenesis
- VernacularTitle:食管上皮癌变过程中FAS、FASL、FADD和caspase-8的表达及其意义
- Author:
Xin XU
;
Lintao PENG
;
Lihua LIU
;
Pei WANG
;
Lianfu ZUO
- Publication Type:Journal Article
- Keywords:
esophageal neoplasms;
apoptosis;
FAS/FASL;
FADD;
caspase-8
- From:
Basic & Clinical Medicine
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of the gene expressions of FAS、FASL、FADD and caspase-8 in esophageal carsinogenesis. Methods Immunohistochemical method was applied to detect the expression of FAS、FASL、FADD and caspase-8 proteins in esophageal epithelium. In situ hybridization method was applied to detect the expression of FADD and caspase-8 mRNA in esophageal epithelium. Results The positive rates of FAS, FADD and caspase-8 proteins and FADD、caspase-8 mRNA were decreased from normal epithelium to dysplasia and carcinoma tissues gradually. The positive rates of FASL protein were increased from normal epithelium to dysplasia and carcinoma tissues gradually. There was very significant statistical difference between carcinoma and normal epithelium(P
