Anti-IL-5 monoclony antibody inhibits the migration of eosinophil in a murine model of asthma
- VernacularTitle:抗白介素5单克隆抗体抑制哮喘小鼠嗜酸性粒细胞迁移
- Author:
Ronglin JIANG
;
Huahao SHEN
;
Shaobing WANG
;
Pinli WANG
;
Weibin MA
- Publication Type:Journal Article
- Keywords:
asthma;
animal model;
eosinophil;
anti-IL-5 monoclony antibody
- From:
Basic & Clinical Medicine
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of anti-IL-5 monoclony antibody (TRFK-5) on migration of Eos from BM to the airways in sensitized mice. Methods Male C57BL/6 (6-8wk of age) murine model of Asthma and control group were estabolished with routine method. The outcome measurements include white blood cell (WBC) total count, differential count of bronchoalveolar lavage fluid (BALF) and peripheral blood (PB), nuclear cell count and eosinophil percentage of BM. These parameters were collected 12 h after the final allergen challenge. To cheek Eos infiltration, the histology of lung tissues was also observed. Further, the effects of intranasal TRFK-5 on above changes were investigated. Results Eosinophil numbers of BALF, PB, BM and the infiltration of Eos in pulmovnary tissues were increased considerably 12 h after final OVA challenge compared with negative group(P
