Outcome of refractory autoimmune thrombocytopenia purpura treated with autologous peripheral blood stem cell transplantation
- VernacularTitle:自体外周血干细胞移植治疗难治性免疫性血小板减少性紫癜及随访
- Author:
Wei ZHANG
;
Daobin ZHOU
;
Yan ZHAO
;
Xiaomei LENG
;
Ying JIANG
;
Ti SHEN
- Publication Type:Journal Article
- Keywords:
Hematopoietic stem cell transplantation;
Autoimmune thrombocytopenia purpura;
Therapeutics
- From:
Basic & Clinical Medicine
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the efficacy and immune reconstitution of autologous peripheral blood stem cell transplantation (APBSCT) in the treatment of refractory autoimmune thrombocytopenia purpura (ITP). MethodsOne patient with refractory ITP was treated with APBSCT, the effectiveness and the process of immune reconstitution were analyzed retrospectively. Results The case was mobilized by cyclophosphamide (CY) plus G-CSF and 4.7?106/kg CD34+ cell was gained totally. Neutrophil and platelet were engrafted at 11th and 12th day without severe complications following the conditioning of TBI and CY. Although the each phenotype of the peripheral blood lymphocytes recovered gradually 6 months after the transplant,inverted CD4/CD8 ratio exited and memory T cell was improved much earlier than naive T cell. The platelete count was constantly over 100?109/L and the patient was in complete remission after a follow-up of 31 months.Conclusion APBSCT is a potential approach in the treatment of refractory ITP.
