Alterations of T Cell Subsets of Epidemic Hemorrhagic Fever During Acute Phase
- VernacularTitle:流行性出血热T淋巴细胞亚群及DP细胞异常改变
- Author:
Yanru LOU
;
Wei LIANG
;
Xiaoping HUANG
;
Liyong YU
;
Qitian MU
;
Yubo SHI
;
Yan DONG
;
Jin ZHANG
- Publication Type:Journal Article
- Keywords:
Epidemic hemorrhagic fever;
Lymphocyte subsets;
CD4+CD8+;
Flow cytometry
- From:
Chinese Journal of Nosocomiology
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To study characteristics of changing T lymphocytes in epidemic hemorrhagic fever(EHF) patients during acute phase and find out the pathogenesis,in order to elevate the level of early diagnosis.METHODS The anticoagulant blood from 30 cases of EHF patients and 50 normal healthy blood donors was collected.T lymphocyte subsets were detected by flow cytometry.RESULTS Compared with those of normal persons,CD4+ T cell counts of EHF patients decreased,CD8+T cell and double CD4+CD8+ cell(double positive cells,DP cell) counts of EHF patients increased obviously,and 25 cases of EHF in recovery stage returned to normal.And in comparison with HIV,CMV and EBV patients,DP cell counts of EHF patients increased obviously.CONCLUSIONS T lymphocytes of EHF decrease obviously but could be resumed,detection of amounts of lymphocyte subsets and CD4+CD8+ cells can provide an early diagnosis method to EHF.
