Mechanism of Protective Immunity Induced by Irradiation-Attenuated Sporozoites and its Implication for Pre-Erythrocytic Malaria Vaccine Research
- VernacularTitle:减毒子孢子诱导小鼠保护性免疫机制及其对红前期疫苗研制的启示
- Author:
Wenyue XU
- Publication Type:Journal Article
- Keywords:
Irradiation-attenuated sporozoite;
Plasmodium;
Vaccine;
Protective immunity
- From:
Chinese Journal of Parasitology and Parasitic Diseases
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Irradiation-attenuated sporozoites are still the most effective pre-erythrocytic malaria vaccine.However,limitation of purified sporozoites and difficulty in attenuation controlling of sporozoites hamper its use in practice.Understanding the mechanism of protective immunity induced by irradiation-attenuated sporozoites will be helpful for the design of the efficient pre-erythrocytic malaria vaccine.This is a review on research progress in the mechanism of protective immunity induced by irradiation-attenuated sporozoites and current status of pre-erythrocytic malaria vaccine development.
