Effect of hyperphosphorylated tau protein on the formation of brain amyloid
- VernacularTitle:Tau蛋白过度磷酸化对脑淀粉样蛋白生成的影响
- Author:
Jianjun LI
;
Zhuyi LI
;
Hongzeng LI
- Publication Type:Journal Article
- Keywords:
Okadaic acid;
tau protein;
hyperphosphorylation;
amyloid
- From:
Journal of Clinical Neurology
1988;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of hyperphosphorylated tau protein on the formation of brain amyloid.Methods Okadaic acid was injected into lateral ventricle of rats, once a day for eight weeks. The place navigation and spatial probe ability of rats were assessed by Morris water maze. Immunohistochemistry techniques were used to detect the expressions of neurofibrillary tangles and amyloid.Results In the Okadaic acid group, the spatial learning and memory abilities of rats were significantly impaired. The mean incubation period of Morris water maze was longer than control group. The accumulation of neurofibrillary tangles and plenty of ?-amyloid positive cells were detected in hippocampus CA1, CA3 and CA4 regions, dentate gyrus and cortex. Deposition of ?-amyloid was observed in hippocampus CA1 and CA3 regions, dentate gyrus and cortex.Conclusion The hyperphosphorylated tau protein may significantly increase deposition of amyloid in brain.
