Effect of Ginsenoside Rg1 on the expression of neuron specific enolase following focal cerebral ischemia in rats and its significance
- VernacularTitle:人参皂甙Rg1对局灶性脑缺血大鼠脑组织神经元特异性烯醇化酶表达的影响及其意义
- Author:
Rongtai CUI
;
Chuanqiang PU
;
Peifu WANG
- Publication Type:Journal Article
- Keywords:
Ginsenoside Rg1;
neuron specific enolase;
cerebral ischemia
- From:
Journal of Clinical Neurology
1988;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect and significance of Ginsenoside Rg1 on the expression of neuron specific enolase (NSE) after focal cerebral ischemia in adult rats.Methods Ginsenoside Rg1 was given intraperitoneally in the rats twice a day at dose of 20 mg/kg for 5 days. Then the models of cerebral ischemia were made by occluding middle cerebral artery using an intraluminal filament method. At 3, 24, 48 and 72 h after focal cerebral ischemia, the neurological deficit score was evaluated and immunohistochemistry technique was used to observe the expressions of NSE. The above parameters were compared to control group and sham operation group.Results Compared with control group,at all the time points the neurological deficit scores were significantly decreased in Ginsenoside Rg1 group (all P
